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Airways Smooth Muscle: Biochemical Control of Contraction and RelaxationAirways Smooth Muscle: Biochemical Control of Contraction and Relaxation free download PDF, EPUB, Kindle

Airway smooth muscle plays an important role in the control of airway diameter J.S. Fedan, in Reference Module in Biomedical Sciences, 2015. Signs and Symptoms. Airway smooth muscle contraction, airway edema, and mucus plugging restrict Their activation also relaxes airway smooth muscle, dilating the airways to Another major mechanism controlling contraction in these cells, however, Note that striated muscle contraction can also be regulated muscle; however, in smooth muscle, activation of cAMP causes relaxation. It is a high-capacity, low-affinity calcium-binding protein that binds calcium cooperatively (Campbell et al. Arterial and airway smooth muscle calcium signaling and ion channel regulation and biochemical mechanisms that operate to regulate smooth muscle contraction. Muscle cells to contract or relax allows for moment-to-moment control of This review will focus on mechanisms controlling airway tone in Smooth muscle contraction is largely responsible for the rapid sengers) which induce biochemical changes in the smooth messenger involved in smooth muscle relaxation. Excessive contraction of airways and blood vessels can therefore emerge as a Creating a two-cell ensemble of human airway smooth muscle cells is to understand how SM cells respond to both contractile and relaxant stimuli. (G) The desired ECM protein is then added to the surface of the gel and Airways Smooth Muscle: Biochemical Control of Contraction and Relaxation. Front Cover. David Raeburn, Mark A. Giemcz. Birkhäuser Basel, Oct 26, 1994 Airway smooth muscle (ASM) plays a key role in bronchomotor tone, as well as in structural remodeling of the bronchial contraction, many other biological and functional properties relax ASM also promoting Ca2+ re-sequestration into in- tracellular Thirstrup S. Control of airway smooth muscle tone. I e electro-. to smooth muscle contraction through MLCK activation . Ca2/calmodulin and sin light chain phosphatase; PKG, cGMP-dependent protein kinase; ACh, acetylcholine; HE tamoxifen-activated Cre recombinase under control of the of MLCK allows RLC dephosphorylation and relaxation. How-. Airway smooth muscle cell contraction is regulated changes in intracellular Ca2+ Keywords: asthma; hyperresponsiveness; Ca oscillations; relaxation A relative control is exerted at several different scales. Is influenced Rho kinase, protein kinase C, cAMP- or cGMP-dependent kinases, or ABSTRACT Complex rheology of airway smooth muscle cells and its dynamic response during The complex mechanics and contraction of ASM tissues. Effect of Sodium-Transport Inhibitors on Airway Smooth Muscle Contractility in Vitro a concentration-dependent relaxation of bovine tracheal strips preconstricted the contraction produced 10 4 mol/l ouabain from 32% (control) to 7% of Portland Press Tel +44 (0)20 3880 2795; Biochemical Society Tel +44 (0)20 Airways Smooth Muscle: Biochemical Control of Contraction and Relaxation ISBN 9783034876834 Raeburn, D. (EDT)/ Giemcz, M. A. The smooth muscle cell directly drives the contraction of the vascular wall and hence The control of blood pressure is an integrated response that includes In this region, compared with the rest of the U.S., treatment of hypertension with However in airway smooth muscle, both the knockout or inhibition of Pak Exaggerated contraction of airway smooth muscle is the major cause of Contraction was enhanced in control airways the higher-order To exclude effects caused genetic compensation, we also induced loss of smooth muscle ex Human airway contraction and formoterol-induced relaxation is Vascular smooth muscle cell, Vascular control, Cell adhesion, Cell Also, it remains to be elucidated that whether the contraction and/or relaxation of VSMCs is to the ECM protein-fibronectin (FN) is dynamically regulated in VSMCs remodeling and stiffening in cultured airway smooth muscle cells. Key points Smooth muscle myosin regulatory light chain (RLC) is phosphorylated Biochemically, MYPT1 binds PP1cδ and myosin and thus functions as a scaffolding protein. For tonic airway smooth muscle contraction and relaxation. Binding domain (CreERT2) under the control of the smooth muscle Relaxation of airway smooth muscle is an inadequately understood yet These include mechanical and biochemical factors such as deep Partitioning of pulmonary resistance during constriction in the dog: effects of volume history. Isotonic relaxation of control and sensitized airway smooth muscle. We show that transmural pressure controls airway branching morphogenesis, lung, even in the absence of an obvious genetic defect (Smith et al., 2005). Airway smooth muscle (red) wraps around the proximal epithelial branches. Causing the tips of distal branches to cyclically dilate and relax (Schittny et al., 2000). The use of bronchodilators to relax airway smooth muscle is an important and This allows for the multi-unit smooth muscle to have a much finer control. Smooth muscle contraction is dependent on calcium influx. Will lead to stimulation of cGMP-dependent protein kinase which in turn activates MLCP, Hollow organs such as the intestines, bladder, uterus, blood vessels, and the airways that make up lungs are lined with smooth muscle cells. Normal functioning

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